Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

The aggregation of the human islet amyloid polypeptide (IAPP) is associated with diabetes type II. A quantitative understanding of this connection at the molecular level requires that the aggregation mechanism of IAPP is resolved in terms of the underlying microscopic steps. Here we have systematica...

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Detalles Bibliográficos
Autores principales: Rodriguez Camargo, Diana C., Chia, Sean, Menzies, Joseph, Mannini, Benedetta, Meisl, Georg, Lundqvist, Martin, Pohl, Christin, Bernfur, Katja, Lattanzi, Veronica, Habchi, Johnny, Cohen, Samuel IA, Knowles, Tuomas P. J, Vendruscolo, Michele, Linse, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591229/
https://www.ncbi.nlm.nih.gov/pubmed/34790701
http://dx.doi.org/10.3389/fmolb.2021.757425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591229/
https://www.ncbi.nlm.nih.gov/pubmed/34790701
http://dx.doi.org/10.3389/fmolb.2021.757425

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