The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that is a therapeutic target in many cancers and inflammatory diseases. BRD4 plays important roles in transcription as an active kinase, which phosphorylates the carboxy-terminal domain (CTD) of RNA polymerase II (Pol II), th...

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Detalles Bibliográficos
Autores principales: Weissman, Jocelyn D., Singh, Amit K., Devaiah, Ballachanda N., Schuck, Peter, LaRue, Ross C., Singer, Dinah S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591364/
https://www.ncbi.nlm.nih.gov/pubmed/34688663
http://dx.doi.org/10.1016/j.jbc.2021.101326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591364/
https://www.ncbi.nlm.nih.gov/pubmed/34688663
http://dx.doi.org/10.1016/j.jbc.2021.101326

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