Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer: Lanatoside C suppresses GRP78 stress induction

The 78 kilodalton glucose-regulated protein (GRP78) is a major endoplasmic reticulum (ER) molecular chaperone with antiapoptotic properties and a key regulator of the unfolded protein response (UPR). ER-stress induction of GRP78 in cancer cells represents a major pro-survival branch of the UPR. Panc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ha, Dat P., Tsai, Yuan-Li, Lee, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591401/
https://www.ncbi.nlm.nih.gov/pubmed/34768108
http://dx.doi.org/10.1016/j.neo.2021.10.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591401/
https://www.ncbi.nlm.nih.gov/pubmed/34768108
http://dx.doi.org/10.1016/j.neo.2021.10.004

Ejemplares similares