Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy

PBX1 is a transcription factor involved in diverse cellular functions including organ development, stem cell renewal, and tumorigenesis. PBX1 is localized at chr1q23.3, a frequently amplified chromosomal region, and it is overexpressed in many human malignancies. Cancer cells with elevated PBX1 sign...

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Detalles Bibliográficos
Autores principales: Shen, Yao-An, Jung, Jin, Shimberg, Geoffrey D., Hsu, Fang-Chi, Rahmanto, Yohan Suryo, Gaillard, Stephanie L., Hong, Jiaxin, Bosch, Jürgen, Shih, Ie-Ming, Chuang, Chi-Mu, Wang, Tian-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591422/
https://www.ncbi.nlm.nih.gov/pubmed/34816098
http://dx.doi.org/10.1016/j.isci.2021.103297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591422/
https://www.ncbi.nlm.nih.gov/pubmed/34816098
http://dx.doi.org/10.1016/j.isci.2021.103297

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