Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

Mechanistic insights into the role of the human microbiome in the predisposition to and treatment of disease are limited by the lack of methods to precisely add or remove microbial strains or genes from complex communities. Here, we demonstrate that engineered bacteriophage M13 can be used to delive...

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Detalles Bibliográficos
Autores principales: Lam, Kathy N., Spanogiannopoulos, Peter, Soto-Perez, Paola, Alexander, Margaret, Nalley, Matthew J., Bisanz, Jordan E., Nayak, Renuka R., Weakley, Allison M., Yu, Feiqiao B., Turnbaugh, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591988/
https://www.ncbi.nlm.nih.gov/pubmed/34731631
http://dx.doi.org/10.1016/j.celrep.2021.109930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591988/
https://www.ncbi.nlm.nih.gov/pubmed/34731631
http://dx.doi.org/10.1016/j.celrep.2021.109930

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