Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12

[Image: see text] CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function. Pathologically, the CXCL12–CXCR4 signaling axis is involved in many cancers and inflammatory diseases and thus has sparke...

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Detalles Bibliográficos
Autores principales: Sprague, Daniel J., Getschman, Anthony E., Fenske, Tyler G., Volkman, Brian F., Smith, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592115/
https://www.ncbi.nlm.nih.gov/pubmed/34795867
http://dx.doi.org/10.1021/acsmedchemlett.1c00388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592115/
https://www.ncbi.nlm.nih.gov/pubmed/34795867
http://dx.doi.org/10.1021/acsmedchemlett.1c00388

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