Cargando…

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12

[Image: see text] CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function. Pathologically, the CXCL12–CXCR4 signaling axis is involved in many cancers and inflammatory diseases and thus has sparke...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sprague, Daniel J., Getschman, Anthony E., Fenske, Tyler G., Volkman, Brian F., Smith, Brian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592115/ https://www.ncbi.nlm.nih.gov/pubmed/34795867 http://dx.doi.org/10.1021/acsmedchemlett.1c00388

Ejemplares similares

Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine
por: Smith, Emmanuel W., et al.
Publicado: (2014)

A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
por: Nguyen, Khanh T.P., et al.
Publicado: (2022)

Design and Synthesis of New 1,3,5‐Trisubstituted Triazines for the Treatment of Cancer and Inflammation
por: Zacharie, Boulos, et al.
Publicado: (2018)

Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands
por: Moussouras, Natasha A., et al.
Publicado: (2017)

Trisubstituted 1,3,5-Triazines as Histamine H(4) Receptor Antagonists with Promising Activity In Vivo
por: Olejarz-Maciej, Agnieszka, et al.
Publicado: (2023)

sym-Trisubstituted 1,3,5-Triazine Derivatives as Promising Organic Corrosion Inhibitors for Steel in Acidic Solution
por: El-Faham, Ayman, et al.
Publicado: (2016)

Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines
por: Oyagawa, Caitlin R. M., et al.
Publicado: (2018)

Erratum: Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines
Publicado: (2019)

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
por: Döring, Yvonne, et al.
Publicado: (2014)

Synthesis and PI 3-Kinase Inhibition Activity of Some Novel 2,4,6-Trisubstituted 1,3,5-Triazines
por: Nelson, Ronald A., et al.
Publicado: (2018)

Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells
por: Koch, Christian, et al.
Publicado: (2022)

Correction: Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells
por: Koch, Christian, et al.
Publicado: (2023)

The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep
por: Ashley, Ryan L, et al.
Publicado: (2011)

Overproduction of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in β-thalassemia major or patients
por: Najmaddini, Hamid, et al.
Publicado: (2014)

Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
por: Chung, Brile, et al.
Publicado: (2017)

Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10
por: Nagel, JE, et al.
Publicado: (2004)

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4
por: Collins, Paul J., et al.
Publicado: (2017)

Inflammation Controls B Lymphopoiesis by Regulating Chemokine CXCL12 Expression
por: Ueda, Yoshihiro, et al.
Publicado: (2004)

The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer
por: Popple, A, et al.
Publicado: (2012)

SDF-1/CXCL12: A Chemokine in the Life Cycle of HIV
por: Arenzana-Seisdedos, Fernando
Publicado: (2015)

CXCL12 chemokine and GABA neurotransmitter systems crosstalk and their putative roles
por: Guyon, Alice
Publicado: (2014)

The chemokines CXCL12 and CXCL14 differentially regulate connective tissue markers during limb development
por: Nassari, Sonya, et al.
Publicado: (2017)

Protein-Ligand interaction studies on 2, 4, 6- trisubstituted triazine derivatives as anti-malarial DHFR agents using AutoDock
por: Adinarayana, Katika Prabhakara Surya, et al.
Publicado: (2011)

Atom-efficient synthesis of 2,4,6-trisubstituted 1,3,5-triazines via Fe-catalyzed cyclization of aldehydes with NH(4)I as the sole nitrogen source
por: Xiao, Jiang, et al.
Publicado: (2020)

Serotonin-Mediated Tuning of Human Helper T Cell Responsiveness to the Chemokine CXCL12
por: Magrini, Elena, et al.
Publicado: (2011)

The Chemokine CXCL12 Is Essential for the Clearance of the Filaria Litomosoides sigmodontis in Resistant Mice
por: Bouchery, Tiffany, et al.
Publicado: (2012)

CXCL12 Chemokine Expression Suppresses Human Pancreatic Cancer Growth and Metastasis
por: Roy, Ishan, et al.
Publicado: (2014)

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
por: Shi, Yi, et al.
Publicado: (2020)

The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
por: Cambier, Seppe, et al.
Publicado: (2023)

Seminal Levels of Pro-inflammatory (CXCL1, CXCL9, CXCL10) and Homeostatic (CXCL12) Chemokines in Men With Asymptomatic Chlamydia trachomatis Infection
por: Hakimi, Hamid, et al.
Publicado: (2014)

Biguanide-Based Synthesis of 1,3,5-Triazine Derivatives with Anticancer Activity and 1,3,5-Triazine Incorporated Calcium Citrate Nanoparticles
por: Chalermnon, Monnaya, et al.
Publicado: (2021)

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology
por: Jayson, Gordon C., et al.
Publicado: (2015)

CXCL1, CXCL10 and CXCL12 Chemokines are Variously Expressed in Acute Myeloid Leukemia Patients Prior and Post Bone Marrow Transplantation
por: Yazdani, Bahar, et al.
Publicado: (2021)

The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis
por: Zielińska, Karolina A., et al.
Publicado: (2020)

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease
por: Bignold, Rebecca, et al.
Publicado: (2022)

Privileged Scaffold Decoration for the Identification of the First Trisubstituted Triazine with Anti-SARS-CoV-2 Activity
por: Cesarini, Silvia, et al.
Publicado: (2022)

4-Amino-2,8-dimethyl-6H-pyrimido[1,2-a][1,3,5]triazin-6-one
por: Sachdeva, Nikhil, et al.
Publicado: (2010)

The longstanding challenge of the nanocrystallization of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX)
por: Pessina, Florent, et al.
Publicado: (2017)

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines
por: Gul, Halise Inci, et al.
Publicado: (2016)

Retraction for Adinarayana & Devi, Protein-Ligand interaction studies on 2, 4, 6-trisubstituted triazine derivatives as anti-malarial DHFR agents using AutoDock
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_csjo19bhhmn118v0vvr5fskluq