Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype

Kdm6a/Utx, a gene on the X chromosome, encodes a histone H3K27me3 demethylase that has an orthologue on the Y chromosome (Uty) (Zheng et al. 2018). We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse acute promyelocytic leukemia samples; however, somatic mutations...

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Detalles Bibliográficos
Autores principales: Tian, Ling, Chavez, Monique, Chang, Gue Su, Helton, Nichole M., Katerndahl, Casey D. S., Miller, Christopher A., Wartman, Lukas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592440/
https://www.ncbi.nlm.nih.gov/pubmed/34780480
http://dx.doi.org/10.1371/journal.pone.0255706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592440/
https://www.ncbi.nlm.nih.gov/pubmed/34780480
http://dx.doi.org/10.1371/journal.pone.0255706

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