Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7

The design of allosteric modulators to control protein function is a key objective in drug discovery programs. Altering functionally essential allosteric residue networks provides unique protein family subtype specificity, minimizes unwanted off-target effects, and helps avert resistance acquisition...

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Detalles Bibliográficos
Autores principales: Pham, N. T. Hang, Létourneau, Myriam, Fortier, Marlène, Bégin, Gabriel, Al-Abdul-Wahid, M. Sameer, Pucci, Fabrizio, Folch, Benjamin, Rooman, Marianne, Chatenet, David, St-Pierre, Yves, Lagüe, Patrick, Calmettes, Charles, Doucet, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592873/
https://www.ncbi.nlm.nih.gov/pubmed/34673030
http://dx.doi.org/10.1016/j.jbc.2021.101308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592873/
https://www.ncbi.nlm.nih.gov/pubmed/34673030
http://dx.doi.org/10.1016/j.jbc.2021.101308

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