The Impact of Mutation L138F/L210F on the Orai Channel: A Molecular Dynamics Simulation Study

The calcium release-activated calcium channel, composed of the Orai channel and the STIM protein, plays a crucial role in maintaining the Ca(2+) concentration in cells. Previous studies showed that the L138F mutation in the human Orai1 creates a constitutively open channel independent of STIM, causi...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoqian, Yu, Hua, Liu, Xiangdong, Song, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592927/
https://www.ncbi.nlm.nih.gov/pubmed/34796201
http://dx.doi.org/10.3389/fmolb.2021.755247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592927/
https://www.ncbi.nlm.nih.gov/pubmed/34796201
http://dx.doi.org/10.3389/fmolb.2021.755247

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