Cargando…

The Impact of Mutation L138F/L210F on the Orai Channel: A Molecular Dynamics Simulation Study

The calcium release-activated calcium channel, composed of the Orai channel and the STIM protein, plays a crucial role in maintaining the Ca(2+) concentration in cells. Previous studies showed that the L138F mutation in the human Orai1 creates a constitutively open channel independent of STIM, causi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiaoqian, Yu, Hua, Liu, Xiangdong, Song, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592927/ https://www.ncbi.nlm.nih.gov/pubmed/34796201 http://dx.doi.org/10.3389/fmolb.2021.755247

Ejemplares similares

cis-4-[(18)F]fluoro-L-proline Molecular Imaging Experimental Liver Fibrosis
por: Cao, Qi, et al.
Publicado: (2020)

Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection
por: Liu, Yin, et al.
Publicado: (2021)

Comparative Molecular Dynamics Simulations Provide Insight Into Antibiotic Interactions: A Case Study Using the Enzyme L,L-Diaminopimelate Aminotransferase (DapL)
por: Adams, Lily E., et al.
Publicado: (2020)

Glycomimetic antagonists of BC2L-C lectin: insights from molecular dynamics simulations
por: Antonini, Giulia, et al.
Publicado: (2023)

The structural, dynamic, and thermodynamic basis of darunavir resistance of a heavily mutated HIV-1 protease using molecular dynamics simulation
por: Shabanpour, Yaser, et al.
Publicado: (2022)

Understanding Thermostability Factors of Barley Limit Dextrinase by Molecular Dynamics Simulations
por: Du, Juan, et al.
Publicado: (2020)

Long Non-coding RNA DLEU2L Targets miR-210-3p to Suppress Gemcitabine Resistance in Pancreatic Cancer Cells via BRCA2 Regulation
por: Xu, Fei, et al.
Publicado: (2021)

Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient
por: Allan, Katelin M., et al.
Publicado: (2023)

Corrigendum: Understanding Thermostability Factors of Barley Limit Dextrinase by Molecular Dynamics Simulations
por: Du, Juan, et al.
Publicado: (2020)

Comparative Genomics of the Conjugation Region of F-like Plasmids: Five Shades of F
por: Fernandez-Lopez, Raul, et al.
Publicado: (2016)

A dynamical view of protein-protein complexes: Studies by molecular dynamics simulations
por: Martin, Juliette, et al.
Publicado: (2022)

Coarse-Grained Modeling and Molecular Dynamics Simulations of Ca(2+)-Calmodulin
por: Nde, Jules, et al.
Publicado: (2021)

Effect of Cholesterol on C99 Dimerization: Revealed by Molecular Dynamics Simulations
por: Li, Cheng-Dong, et al.
Publicado: (2022)

Substrate Specificity of Cysteine Proteases Beyond the S(2) Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L
por: Corvo, Ileana, et al.
Publicado: (2018)

Non-RBM Mutations Impaired SARS-CoV-2 Spike Protein Regulated to the ACE2 Receptor Based on Molecular Dynamic Simulation
por: Du, Yaoqiang, et al.
Publicado: (2021)

Orai1-mediated store-operated Ca(2+) entry promotes cervical cancer progression through IL-6 signaling
por: Pan, Yiyun, et al.
Publicado: (2022)

Integrating atomistic molecular dynamics simulations, experiments, and network analysis to study protein dynamics: strength in unity
por: Papaleo, Elena
Publicado: (2015)

Effects of a plant cyclotide on conformational dynamics and destabilization of β-amyloid fibrils through molecular dynamics simulations
por: Kalmankar, Neha V., et al.
Publicado: (2022)

Single-Molecule Microscopy Meets Molecular Dynamics Simulations for Characterizing the Molecular Action of Proteins on DNA and in Liquid Condensates
por: Kamagata, Kiyoto
Publicado: (2021)

Editorial: Recent advancements in modeling and simulations of ion channels
por: Furini, Simone, et al.
Publicado: (2022)

Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery
por: Bunker, Alex, et al.
Publicado: (2020)

Fibril Surface-Dependent Amyloid Precursors Revealed by Coarse-Grained Molecular Dynamics Simulation
por: Ma, Yuan-Wei, et al.
Publicado: (2021)

Editorial: Advanced Sampling and Modeling in Molecular Simulations for Slow and Large-Scale Biomolecular Dynamics
por: Chu, Xiakun, et al.
Publicado: (2021)

Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers
por: Khaled, Mohammed, et al.
Publicado: (2023)

Inhibitory to non-inhibitory evolution of the ζ subunit of the F(1)F(O)-ATPase of Paracoccus denitrificans and α-proteobacteria as related to mitochondrial endosymbiosis
por: Mendoza-Hoffmann, Francisco, et al.
Publicado: (2023)

LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis
por: Mei, Haijun, et al.
Publicado: (2021)

X-Ray Causes mRNA Transcripts Change to Enhance Orai2-Mediated Ca(2+) Influx in Rat Brain Microvascular Endothelial Cells
por: Xu, Fangfang, et al.
Publicado: (2021)

Improved Modeling of Peptide-Protein Binding Through Global Docking and Accelerated Molecular Dynamics Simulations
por: Wang, Jinan, et al.
Publicado: (2019)

Exploring the deactivation mechanism of human β (2) adrenergic receptor by accelerated molecular dynamic simulations
por: Chen, Jianzhong, et al.
Publicado: (2022)

Corrigendum: Fibril Surface-Dependent Amyloid Precursors Revealed by Coarse-Grained Molecular Dynamics Simulation
por: Ma, Yuan-Wei, et al.
Publicado: (2022)

The Multifaceted Activity of the VirF Regulatory Protein in the Shigella Lifestyle
por: Di Martino, Maria Letizia, et al.
Publicado: (2016)

Exploring Allosteric Signaling in the Exit Tunnel of the Bacterial Ribosome by Molecular Dynamics Simulations and Residue Network Model
por: Guzel, Pelin, et al.
Publicado: (2020)

Investigation of the Effect of Temperature on the Structure of SARS-CoV-2 Spike Protein by Molecular Dynamics Simulations
por: Rath, Soumya Lipsa, et al.
Publicado: (2020)

Characterizing the Binding Sites for GK Domain of DLG1 and DLG4 via Molecular Dynamics Simulation
por: Li, Hongwei, et al.
Publicado: (2020)

Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer’s Disease Protofibril Core
por: Leonard, Cass, et al.
Publicado: (2021)

Mechanism for the Unfolding of the TOP7 Protein in Steered Molecular Dynamics Simulations as Revealed by Mutual Information Analysis
por: Perišić, Ognjen, et al.
Publicado: (2021)

Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation
por: Parate, Shraddha, et al.
Publicado: (2021)

ATP binding by an F(1)F(o) ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria
por: Krah, Alexander, et al.
Publicado: (2023)

E2F1: Cause and Consequence of DNA Replication Stress
por: Fouad, Shahd, et al.
Publicado: (2021)

An Unbound Proline-Rich Signaling Peptide Frequently Samples Cis Conformations in Gaussian Accelerated Molecular Dynamics Simulations
por: Alcantara, Juan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rjtc6k2ir7acc70cllcn50u47u