Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease

Chronic kidney diseaQueryse (CKD) is associated with oxidative stress which can interrupt the nitric oxide (NO)/soluble guanylyl cyclase (sGC) signaling and decrease cyclic guanosine monophosphate (cGMP) production. Low cGMP concentrations can cause kidney damage and progression of CKD. The novel sG...

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Detalles Bibliográficos
Autores principales: Bénardeau, Agnès, Kahnert, Antje, Schomber, Tibor, Meyer, Jutta, Pavkovic, Mira, Kretschmer, Axel, Lawrenz, Bettina, Hartmann, Elke, Mathar, Ilka, Hueser, Joerg, Kraehling, Jan R., Eitner, Frank, Hahn, Michael G., Stasch, Johannes-Peter, Sandner, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592982/
https://www.ncbi.nlm.nih.gov/pubmed/34550407
http://dx.doi.org/10.1007/s00210-021-02149-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592982/
https://www.ncbi.nlm.nih.gov/pubmed/34550407
http://dx.doi.org/10.1007/s00210-021-02149-4

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