Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

Brain inflammation generally accompanies and accelerates neurodegeneration. Here we report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses extrinsic tau 3R/4R proteins by direct interaction and triggers an innate immune response by activating a cyclic GMP-AMP synthase...

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Detalles Bibliográficos
Autores principales: Jin, Meihua, Shiwaku, Hiroki, Tanaka, Hikari, Obita, Takayuki, Ohuchi, Sakurako, Yoshioka, Yuki, Jin, Xiaocen, Kondo, Kanoh, Fujita, Kyota, Homma, Hidenori, Nakajima, Kazuyuki, Mizuguchi, Mineyuki, Okazawa, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592984/
https://www.ncbi.nlm.nih.gov/pubmed/34782623
http://dx.doi.org/10.1038/s41467-021-26851-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592984/
https://www.ncbi.nlm.nih.gov/pubmed/34782623
http://dx.doi.org/10.1038/s41467-021-26851-2

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