Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production

Ergothioneine (EGT) is a low molecular weight histidine betaine essential in all domains of life but only synthesized by selected few organisms. Synthesis of EGT by Mycobacterium tuberculosis (M. tb) is critical for maintaining bioenergetic homeostasis and protecting the bacterium from alkylating ag...

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Detalles Bibliográficos
Autores principales: Sudasinghe, Thanuja D., Banco, Michael T., Ronning, Donald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593015/
https://www.ncbi.nlm.nih.gov/pubmed/34782676
http://dx.doi.org/10.1038/s41598-021-01526-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593015/
https://www.ncbi.nlm.nih.gov/pubmed/34782676
http://dx.doi.org/10.1038/s41598-021-01526-6

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