Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures

ASH1L, a histone methyltransferase, is identified as a top-ranking risk factor for autism spectrum disorder (ASD), however, little is known about the biological mechanisms underlying the link of ASH1L haploinsufficiency to ASD. Here we show that ASH1L expression and H3K4me3 level are significantly d...

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Detalles Bibliográficos
Autores principales: Qin, Luye, Williams, Jamal B., Tan, Tao, Liu, Tiaotiao, Cao, Qing, Ma, Kaijie, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593046/
https://www.ncbi.nlm.nih.gov/pubmed/34782621
http://dx.doi.org/10.1038/s41467-021-26972-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593046/
https://www.ncbi.nlm.nih.gov/pubmed/34782621
http://dx.doi.org/10.1038/s41467-021-26972-8

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