Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

Dimethylated histone H3 Lys36 (H3K36me2) regulates gene expression, and aberrant H3K36me2 upregulation, resulting from either the overexpression or point mutation of the dimethyltransferase NSD2, is found in various cancers. Here we report the cryo-electron microscopy structure of NSD2 bound to the...

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Detalles Bibliográficos
Autores principales: Sato, Ko, Kumar, Amarjeet, Hamada, Keisuke, Okada, Chikako, Oguni, Asako, Machiyama, Ayumi, Sakuraba, Shun, Nishizawa, Tomohiro, Nureki, Osamu, Kono, Hidetoshi, Ogata, Kazuhiro, Sengoku, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593083/
https://www.ncbi.nlm.nih.gov/pubmed/34782608
http://dx.doi.org/10.1038/s41467-021-26913-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593083/
https://www.ncbi.nlm.nih.gov/pubmed/34782608
http://dx.doi.org/10.1038/s41467-021-26913-5

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