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Detrimental proarrhythmogenic interaction of Ca(2+)/calmodulin-dependent protein kinase II and Na(V)1.8 in heart failure
An interplay between Ca(2+)/calmodulin-dependent protein kinase IIδc (CaMKIIδc) and late Na(+) current (I(NaL)) is known to induce arrhythmias in the failing heart. Here, we elucidate the role of the sodium channel isoform Na(V)1.8 for CaMKIIδc-dependent proarrhythmia. In a CRISPR-Cas9-generated hum...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593192/ https://www.ncbi.nlm.nih.gov/pubmed/34782600 http://dx.doi.org/10.1038/s41467-021-26690-1 |