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Detrimental proarrhythmogenic interaction of Ca(2+)/calmodulin-dependent protein kinase II and Na(V)1.8 in heart failure

An interplay between Ca(2+)/calmodulin-dependent protein kinase IIδc (CaMKIIδc) and late Na(+) current (I(NaL)) is known to induce arrhythmias in the failing heart. Here, we elucidate the role of the sodium channel isoform Na(V)1.8 for CaMKIIδc-dependent proarrhythmia. In a CRISPR-Cas9-generated hum...

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Detalles Bibliográficos
Autores principales:	Bengel, Philipp, Dybkova, Nataliya, Tirilomis, Petros, Ahmad, Shakil, Hartmann, Nico, A. Mohamed, Belal, Krekeler, Miriam Celine, Maurer, Wiebke, Pabel, Steffen, Trum, Maximilian, Mustroph, Julian, Gummert, Jan, Milting, Hendrik, Wagner, Stefan, Ljubojevic-Holzer, Senka, Toischer, Karl, Maier, Lars S., Hasenfuss, Gerd, Streckfuss-Bömeke, Katrin, Sossalla, Samuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593192/ https://www.ncbi.nlm.nih.gov/pubmed/34782600 http://dx.doi.org/10.1038/s41467-021-26690-1

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