Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine. L-asparaginase (ASNase) converts glutamine and asparagine to glutamate and asparta...

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Detalles Bibliográficos
Autores principales: Okuda, Keiichiro, Umemura, Atsushi, Kataoka, Seita, Yano, Kota, Takahashi, Aya, Okishio, Shinya, Taketani, Hiroyoshi, Seko, Yuya, Nishikawa, Taichiro, Yamaguchi, Kanji, Moriguchi, Michihisa, Nakagawa, Hayato, Liu, Yu, Mitsumoto, Yasuhide, Kanbara, Yoshihiro, Shima, Toshihide, Okanoue, Takeshi, Itoh, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593418/
https://www.ncbi.nlm.nih.gov/pubmed/34796113
http://dx.doi.org/10.3389/fonc.2021.758549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593418/
https://www.ncbi.nlm.nih.gov/pubmed/34796113
http://dx.doi.org/10.3389/fonc.2021.758549

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