Cargando…

Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine. L-asparaginase (ASNase) converts glutamine and asparagine to glutamate and asparta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okuda, Keiichiro, Umemura, Atsushi, Kataoka, Seita, Yano, Kota, Takahashi, Aya, Okishio, Shinya, Taketani, Hiroyoshi, Seko, Yuya, Nishikawa, Taichiro, Yamaguchi, Kanji, Moriguchi, Michihisa, Nakagawa, Hayato, Liu, Yu, Mitsumoto, Yasuhide, Kanbara, Yoshihiro, Shima, Toshihide, Okanoue, Takeshi, Itoh, Yoshito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593418/ https://www.ncbi.nlm.nih.gov/pubmed/34796113 http://dx.doi.org/10.3389/fonc.2021.758549

Ejemplares similares

Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells
por: Kataoka, Seita, et al.
Publicado: (2021)

Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor—MIG6 Axis
por: Okuda, Keiichiro, et al.
Publicado: (2021)

Effect of Sodium Glucose Cotransporter 2 Inhibitors on Renal Function in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Japan
por: Yano, Kota, et al.
Publicado: (2020)

Tyrosine Kinase Inhibitors Stimulate HLA Class I Expression by Augmenting the IFNγ/STAT1 Signaling in Hepatocellular Carcinoma Cells
por: Takahashi, Aya, et al.
Publicado: (2021)

FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
por: Seko, Yuya, et al.
Publicado: (2019)

The Association between the Platelet Count and Liver Volume in Compensated Cirrhosis Patients after the Eradication of Hepatitis C virus by Direct-acting Antivirals
por: Seko, Yuya, et al.
Publicado: (2020)

Potential Therapeutic Targets and Promising Agents for Combating NAFLD
por: Umemura, Atsushi, et al.
Publicado: (2022)

The Appropriate Opportunity for Evaluating Liver Fibrosis by Using the FIB-4 Index in Patients with Nonalcoholic Fatty Liver Disease in Japan
por: Seko, Yuya, et al.
Publicado: (2020)

The Effect of Genetic Polymorphism in Response to Body Weight Reduction in Japanese Patients with Nonalcoholic Fatty Liver Disease
por: Seko, Yuya, et al.
Publicado: (2021)

The additive effect of genetic and metabolic factors in the pathogenesis of nonalcoholic fatty liver disease
por: Seko, Yuya, et al.
Publicado: (2022)

PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
por: Okishio, Shinya, et al.
Publicado: (2020)

Efficacy and safety of canagliflozin in type 2 diabetes mellitus patients with biopsy-proven nonalcoholic steatohepatitis classified as stage 1–3 fibrosis
por: Seko, Yuya, et al.
Publicado: (2018)

Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease
por: Yamaguchi, Kanji, et al.
Publicado: (2023)

Epidemiology, Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan
por: Sumida, Yoshio, et al.
Publicado: (2020)

Aging-associated impairment in metabolic compensation by subcutaneous adipose tissue promotes diet-induced fatty liver disease in mice
por: Taketani, Hiroyoshi, et al.
Publicado: (2019)

Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach
por: Soda, Tomohiro, et al.
Publicado: (2022)

Early Tumor Shrinkage as a Predictive Factor for Outcomes in Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter Analysis
por: Takahashi, Aya, et al.
Publicado: (2020)

Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions
por: Fujii, Hideki, et al.
Publicado: (2017)

Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan
por: Sakakida, Tomoki, et al.
Publicado: (2023)

Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers
por: Kawaguchi, Takahisa, et al.
Publicado: (2018)

A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus
por: Moriguchi, Michihisa, et al.
Publicado: (2017)

EVI1, a target gene for amplification at 3q26, antagonizes transforming growth factor-β-mediated growth inhibition in hepatocellular carcinoma
por: Yasui, Kohichiroh, et al.
Publicado: (2015)

Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
por: Mitsuyoshi, Hironori, et al.
Publicado: (2013)

Garcin Syndrome Due to Meningeal Carcinomatosis from Gastric Cancer
por: Terasaki, Kei, et al.
Publicado: (2020)

Retroperitoneal Perforation Caused by Migration of a Pancreatic Spontaneous Dislodgement Stent into Periampullary Diverticula
por: Nishiwaki, Masatake, et al.
Publicado: (2017)

Mitochondrial Nutrition as a Strategy for Neuroprotection in Parkinson's Disease—Research Focus in the Department of Alternative Medicine and Experimental Therapeutics at Hokuriku University
por: Mitsumoto, Yasuhide
Publicado: (2007)

Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes
por: Ishiba, Hiroshi, et al.
Publicado: (2020)

Correction to: Hepatocellular carcinoma diagnosis using a novel electrochemiluminescence immunoassay targeting serum IgM‑free AIM
por: Shimizu, Tomo, et al.
Publicado: (2022)

Hepatocellular carcinoma diagnosis using a novel electrochemiluminescence immunoassay targeting serum IgM-free AIM
por: Shimizu, Tomo, et al.
Publicado: (2022)

Protocol for acquiring samples to assess the impact of microplastics on immune microenvironments in the mouse intestine
por: Harusato, Akihito, et al.
Publicado: (2023)

Comparison of the effect of light alcohol consumption on Japanese men with and without fatty liver
por: Hara, Tasuku, et al.
Publicado: (2019)

Comparison of the effect of light alcohol consumption on Japanese men with and without fatty liver
por: Hara, Tasuku, et al.
Publicado: (2020)

Procedure of Direct Hepatic Artery Puncture for the Treatment of Hepatocellular Carcinoma: Two Case Reports
por: Takashima, Hidetaka, et al.
Publicado: (2020)

A Simple Method to Avoid Bile Duct Injury during Percutaneous Radiofrequency Ablation Therapy for Hepatocellular Carcinoma
por: Takashima, Hidetaka, et al.
Publicado: (2020)

Eosinophilic Cholangitis with Poor Prognosis after Corticosteroid- and Ursodeoxycholic Acid-Related Remission of Peripheral and Peribiliary Eosinophilia
por: Shimomura, Takahito, et al.
Publicado: (2021)

Why People Play: Artificial Lives Acquiring Play Instinct to Stabilize Productivity
por: Tamura, Shinichi, et al.
Publicado: (2012)

Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population
por: Ohmoto, Masanori, et al.
Publicado: (2014)

Multi-modality imaging of high-intensity plaques on non-contrast T1-weighted magnetic resonance imaging: a case report
por: Hosoda, Hayato, et al.
Publicado: (2023)

Development of an automated size-based filtration system for isolation of circulating tumor cells in lung cancer patients
por: Yagi, Satomi, et al.
Publicado: (2017)

Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease
por: Muroyama, Akiko, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_u71rss00lge7qpqhtpaitmanqg