Berberine Improves Irinotecan-Induced Intestinal Mucositis Without Impairing the Anti-colorectal Cancer Efficacy of Irinotecan by Inhibiting Bacterial β-glucuronidase

Irinotecan (CPT11), a broad-spectrum cytotoxic anticancer agent, induces a series of toxic side-effects. The most conspicuous side-effect is gastrointestinal mucositis, including nausea, vomiting, and diarrhea. A growing body of evidence indicates that bacteria β-glucuronidase (GUS), an enzyme expre...

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Detalles Bibliográficos
Autores principales: Yue, Bei, Gao, Ruiyang, Lv, Cheng, Yu, Zhilun, Wang, Hao, Geng, Xiaolong, Wang, Zhengtao, Dou, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593678/
https://www.ncbi.nlm.nih.gov/pubmed/34795594
http://dx.doi.org/10.3389/fphar.2021.774560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593678/
https://www.ncbi.nlm.nih.gov/pubmed/34795594
http://dx.doi.org/10.3389/fphar.2021.774560

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