SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 infected epithelial cell lines reveals that the...

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Detalles Bibliográficos
Autores principales: Yoo, Ji-Seung, Sasaki, Michihito, Cho, Steven X., Kasuga, Yusuke, Zhu, Baohui, Ouda, Ryota, Orba, Yasuko, de Figueiredo, Paul, Sawa, Hirofumi, Kobayashi, Koichi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594428/
https://www.ncbi.nlm.nih.gov/pubmed/34782627
http://dx.doi.org/10.1038/s41467-021-26910-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594428/
https://www.ncbi.nlm.nih.gov/pubmed/34782627
http://dx.doi.org/10.1038/s41467-021-26910-8

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