A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels

Proton-gated ion channels conduct mainly Na(+) to induce postsynaptic membrane depolarization. Finding the determinants of ion selectivity requires knowledge of the pore structure in the open conformation, but such information is not yet available. Here, the open conformation of the hASIC1a channel...

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Detalles Bibliográficos
Autores principales: Chen, Zhuyuan, Lin, Sheng, Xie, Tianze, Lin, Jin-Ming, Canessa, Cecilia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594623/
https://www.ncbi.nlm.nih.gov/pubmed/34766968
http://dx.doi.org/10.1085/jgp.202112978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594623/
https://www.ncbi.nlm.nih.gov/pubmed/34766968
http://dx.doi.org/10.1085/jgp.202112978

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