Enhancement of the Antileukemic Action of the Inhibitors of DNA and Histone Methylation: 5-Aza-2′-Deoxycytidine and 3-Deazaneplanocin-A by Vitamin C

Epigenetic gene silencing by DNA methylation and histone methylation by EZH2 play an important role in the development of acute myeloid leukemia (AML). EZH2 catalyzes the trimethylation of histone H3-lysine 27-trimethylated (H3K27me3). These epigenetic alterations silence the expression of the genes...

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Detalles Bibliográficos
Autores principales: Momparler, Richard L., Côté, Sylvie, Momparler, Louise F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594729/
https://www.ncbi.nlm.nih.gov/pubmed/34968294
http://dx.doi.org/10.3390/epigenomes5020007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594729/
https://www.ncbi.nlm.nih.gov/pubmed/34968294
http://dx.doi.org/10.3390/epigenomes5020007

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