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Comparative Physical Study of Three Pharmaceutically Active Benzodiazepine Derivatives: Crystalline versus Amorphous State and Crystallization Tendency

[Image: see text] Chemical derivatization and amorphization are two possible strategies to improve the solubility and bioavailability of drugs, which is a key issue for the pharmaceutical industry. In this contribution, we explore whether both strategies can be combined by studying how small differe...

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Detalles Bibliográficos
Autores principales: Valenti, Sofia, Barrio, Maria, Negrier, Philippe, Romanini, Michela, Macovez, Roberto, Tamarit, Josep-Lluis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594866/
https://www.ncbi.nlm.nih.gov/pubmed/33689364
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00081