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Osteolytic effects of tumoral estrogen signaling in an estrogen receptor-positive breast cancer bone metastasis model

AIM: Estrogen receptor α-positive (ER+) subtypes of breast cancer have the greatest predilection for forming osteolytic bone metastases (BMETs). Because tumor-derived factors mediate osteolysis, a possible role for tumoral ERα signaling in driving ER+ BMET osteolysis was queried using an estrogen (E...

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Detalles Bibliográficos
Autores principales: Cheng, Julia N., Frye, Jennifer B., Whitman, Susan A., Kunihiro, Andrew G., Brickey, Julia A., Funk, Janet L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594878/
https://www.ncbi.nlm.nih.gov/pubmed/34790880
http://dx.doi.org/10.20517/2394-4722.2021.27