Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

Progenitors of the thoracic tracheal system of adult Drosophila (tracheoblasts) arrest in G2 during larval life and rekindle a mitotic program subsequently. G2 arrest is dependent on ataxia telangiectasia mutated and rad3-related kinase (ATR)-dependent phosphorylation of checkpoint kinase 1 (Chk1) t...

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Detalles Bibliográficos
Autores principales: Kizhedathu, Amrutha, Chhajed, Piyush, Yeramala, Lahari, Sain Basu, Deblina, Mukherjee, Tina, Vinothkumar, Kutti R, Guha, Arjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594940/
https://www.ncbi.nlm.nih.gov/pubmed/34622778
http://dx.doi.org/10.7554/eLife.68636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594940/
https://www.ncbi.nlm.nih.gov/pubmed/34622778
http://dx.doi.org/10.7554/eLife.68636

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