Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats

BACKGROUND: Astrocyte A1/A2 phenotypes may play differential role in the pathogenesis of periventricular white matter (PWM) damage in septic postnatal rats. This study aimed to determine whether melatonin (MEL) would improve the axonal hypomyelination through shifting A1 astrocytes towards A2. METHO...

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Detalles Bibliográficos
Autores principales: Jiang, Shuqi, Wang, Huifang, Zhou, Qiuping, Li, Qian, Liu, Nan, Li, Zhenggong, Chen, Chunbo, Deng, Yiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595063/
https://www.ncbi.nlm.nih.gov/pubmed/34803390
http://dx.doi.org/10.2147/JIR.S337499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595063/
https://www.ncbi.nlm.nih.gov/pubmed/34803390
http://dx.doi.org/10.2147/JIR.S337499

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