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(-)-T-Cadinol—a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)—Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Trypanosoma cruzi
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 6–8 million people worldwide, mainly from developing countries. The treatment is limited to two approved nitro-derivatives, nifurtimox and benznidazole, with several side effects and reduced efficacy. Casearia sylvestri...
Autores principales: | dos Santos, Augusto L., Amaral, Maiara, Hasegawa, Flavia Rie, Lago, João Henrique G., Tempone, Andre G., Sartorelli, Patricia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595124/ https://www.ncbi.nlm.nih.gov/pubmed/34803682 http://dx.doi.org/10.3389/fphar.2021.734127 |
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