Pharmacokinetics and Disposition of Heparin-Binding Growth Factor Midkine Antisense Oligonucleotide Nanoliposomes in Experimental Animal Species and Prediction of Human Pharmacokinetics Using a Physiologically Based Pharmacokinetic Model

Encapsulating the antisense oligonucleotide drug MK-ASODN with nanoliposomes greatly improved its potency and targeting to the heparin-binding growth factor midkine. The disposition and pharmacokinetic (PK) parameters of MK-ASODN nanoliposomes were studied in monkeys and rats, and the human PK param...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Haihong, Cheng, Yuanguo, Che, Jinjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595129/
https://www.ncbi.nlm.nih.gov/pubmed/34803711
http://dx.doi.org/10.3389/fphar.2021.769538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595129/
https://www.ncbi.nlm.nih.gov/pubmed/34803711
http://dx.doi.org/10.3389/fphar.2021.769538

Ejemplares similares