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Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer
Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vac...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595142/ https://www.ncbi.nlm.nih.gov/pubmed/34838186 http://dx.doi.org/10.1016/j.ccell.2021.11.006 |
| _version_ | 1784600132797333504 |
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| author | Shapiro, Lauren C. Thakkar, Astha Campbell, Sean T. Forest, Stefanie K. Pradhan, Kith Gonzalez-Lugo, Jesus D. Quinn, Ryann Bhagat, Tushar D. Choudhary, Gaurav S. McCort, Margaret Sica, R. Alejandro Goldfinger, Mendel Goel, Swati Anampa, Jesus D. Levitz, David Fromowitz, Ariel Shah, Akash Pradip Sklow, Charlotte Alfieri, Gregory Racine, Andrew Wolgast, Lucia Greenberger, Lee Verma, Amit Halmos, Balazs |
| author_facet | Shapiro, Lauren C. Thakkar, Astha Campbell, Sean T. Forest, Stefanie K. Pradhan, Kith Gonzalez-Lugo, Jesus D. Quinn, Ryann Bhagat, Tushar D. Choudhary, Gaurav S. McCort, Margaret Sica, R. Alejandro Goldfinger, Mendel Goel, Swati Anampa, Jesus D. Levitz, David Fromowitz, Ariel Shah, Akash Pradip Sklow, Charlotte Alfieri, Gregory Racine, Andrew Wolgast, Lucia Greenberger, Lee Verma, Amit Halmos, Balazs |
| author_sort | Shapiro, Lauren C. |
| collection | PubMed |
| description | Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy. |
| format | Online Article Text |
| id | pubmed-8595142 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85951422021-11-17 Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer Shapiro, Lauren C. Thakkar, Astha Campbell, Sean T. Forest, Stefanie K. Pradhan, Kith Gonzalez-Lugo, Jesus D. Quinn, Ryann Bhagat, Tushar D. Choudhary, Gaurav S. McCort, Margaret Sica, R. Alejandro Goldfinger, Mendel Goel, Swati Anampa, Jesus D. Levitz, David Fromowitz, Ariel Shah, Akash Pradip Sklow, Charlotte Alfieri, Gregory Racine, Andrew Wolgast, Lucia Greenberger, Lee Verma, Amit Halmos, Balazs Cancer Cell Letter Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy. Elsevier Inc. 2022-01-10 2021-11-16 /pmc/articles/PMC8595142/ /pubmed/34838186 http://dx.doi.org/10.1016/j.ccell.2021.11.006 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Letter Shapiro, Lauren C. Thakkar, Astha Campbell, Sean T. Forest, Stefanie K. Pradhan, Kith Gonzalez-Lugo, Jesus D. Quinn, Ryann Bhagat, Tushar D. Choudhary, Gaurav S. McCort, Margaret Sica, R. Alejandro Goldfinger, Mendel Goel, Swati Anampa, Jesus D. Levitz, David Fromowitz, Ariel Shah, Akash Pradip Sklow, Charlotte Alfieri, Gregory Racine, Andrew Wolgast, Lucia Greenberger, Lee Verma, Amit Halmos, Balazs Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer |
| title | Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer |
| title_full | Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer |
| title_fullStr | Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer |
| title_full_unstemmed | Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer |
| title_short | Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer |
| title_sort | efficacy of booster doses in augmenting waning immune responses to covid-19 vaccine in patients with cancer |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595142/ https://www.ncbi.nlm.nih.gov/pubmed/34838186 http://dx.doi.org/10.1016/j.ccell.2021.11.006 |
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