Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor α-mediated NF-κB Signaling Pathway in Macrophages

Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause is widely accepted to be wear particle-induced activation of inflammatory macrophages. No effective strategy for the prevention and treatment of periprosthetic osteolysis is yet availab...

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Detalles Bibliográficos
Autores principales: Guangtao, Fu, Zhenkang, Wen, Zhantao, Deng, Mengyuan, Li, Qingtian, Li, Yuanchen, Ma, Yuanfeng, Chen, Qiujian, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595199/
https://www.ncbi.nlm.nih.gov/pubmed/34803690
http://dx.doi.org/10.3389/fphar.2021.746391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595199/
https://www.ncbi.nlm.nih.gov/pubmed/34803690
http://dx.doi.org/10.3389/fphar.2021.746391

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