Dramatic activation of an antibody by a single amino acid change in framework

Antibody function is typically entirely dictated by the Complementarity Determining Regions (CDRs) that directly bind to the antigen, while the framework region acts as a scaffold for the CDRs and maintains overall structure of the variable domain. We recently reported that the rabbit monoclonal ant...

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Detalles Bibliográficos
Autores principales: Liang, Wei-Ching, Yin, Jianping, Lupardus, Patrick, Zhang, Jianhuan, Loyet, Kelly M., Sudhamsu, Jawahar, Wu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595303/
https://www.ncbi.nlm.nih.gov/pubmed/34785671
http://dx.doi.org/10.1038/s41598-021-01530-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595303/
https://www.ncbi.nlm.nih.gov/pubmed/34785671
http://dx.doi.org/10.1038/s41598-021-01530-w

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