mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation

The mammalian target of rapamycin (mTORC1) has been shown to regulate autophagy at different steps. However, how mTORC1 regulates the N-ethylmaleimide-sensitive protein receptor (SNARE) complex remains elusive. Here we show that mTORC1 inhibits formation of the SNARE complex (STX17-SNAP29-VAMP8) by...

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Detalles Bibliográficos
Autores principales: Huang, Hong, Ouyang, Qinqin, Zhu, Min, Yu, Haijia, Mei, Kunrong, Liu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595342/
https://www.ncbi.nlm.nih.gov/pubmed/34785650
http://dx.doi.org/10.1038/s41467-021-26824-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595342/
https://www.ncbi.nlm.nih.gov/pubmed/34785650
http://dx.doi.org/10.1038/s41467-021-26824-5

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