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Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity

To migrate efficiently to target locations, cells must integrate receptor inputs while maintaining polarity: a distinct front that leads and a rear that follows. Here we investigate what is necessary to overwrite pre-existing front-rear polarity in neutrophil-like HL60 cells migrating inside straigh...

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Detalles Bibliográficos
Autores principales: Hadjitheodorou, Amalia, Bell, George R. R., Ellett, Felix, Shastry, Shashank, Irimia, Daniel, Collins, Sean R., Theriot, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595366/
https://www.ncbi.nlm.nih.gov/pubmed/34785640
http://dx.doi.org/10.1038/s41467-021-26622-z