Catalytic enantioselective reductive domino alkyl arylation of acrylates via nickel/photoredox catalysis

Nonsteroidal anti-inflammatory drug derivatives (NSAIDs) are an important class of medications. Here we show a visible-light-promoted photoredox/nickel catalyzed approach to construct enantioenriched NSAIDs via a three-component alkyl arylation of acrylates. This reductive cross-electrophile couplin...

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Detalles Bibliográficos
Autores principales: Qian, Pengcheng, Guan, Haixing, Wang, Yan-En, Lu, Qianqian, Zhang, Fan, Xiong, Dan, Walsh, Patrick J., Mao, Jianyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595378/
https://www.ncbi.nlm.nih.gov/pubmed/34785647
http://dx.doi.org/10.1038/s41467-021-26794-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595378/
https://www.ncbi.nlm.nih.gov/pubmed/34785647
http://dx.doi.org/10.1038/s41467-021-26794-8

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