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Catalytic enantioselective reductive domino alkyl arylation of acrylates via nickel/photoredox catalysis

Nonsteroidal anti-inflammatory drug derivatives (NSAIDs) are an important class of medications. Here we show a visible-light-promoted photoredox/nickel catalyzed approach to construct enantioenriched NSAIDs via a three-component alkyl arylation of acrylates. This reductive cross-electrophile couplin...

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Detalles Bibliográficos
Autores principales:	Qian, Pengcheng, Guan, Haixing, Wang, Yan-En, Lu, Qianqian, Zhang, Fan, Xiong, Dan, Walsh, Patrick J., Mao, Jianyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595378/ https://www.ncbi.nlm.nih.gov/pubmed/34785647 http://dx.doi.org/10.1038/s41467-021-26794-8

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