Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation

During systemic inflammation, indoleamine 2,3-dioxygenase 1 (IDO1) becomes expressed in endothelial cells where it uses hydrogen peroxide (H(2)O(2)) to oxidize L-tryptophan to the tricyclic hydroperoxide, cis-WOOH, that then relaxes arteries via oxidation of protein kinase G 1α. Here we show that ar...

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Detalles Bibliográficos
Autores principales: Queiroz, Raphael F., Stanley, Christopher P., Wolhuter, Kathryn, Kong, Stephanie M. Y., Rajivan, Ragul, McKinnon, Naomi, Nguyen, Giang T. H., Roveri, Antonella, Guttzeit, Sebastian, Eaton, Philip, Donald, William A., Ursini, Fulvio, Winterbourn, Christine C., Ayer, Anita, Stocker, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595612/
https://www.ncbi.nlm.nih.gov/pubmed/34785665
http://dx.doi.org/10.1038/s41467-021-26991-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595612/
https://www.ncbi.nlm.nih.gov/pubmed/34785665
http://dx.doi.org/10.1038/s41467-021-26991-5

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