TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change

Small-cell lung cancer (SCLC), an aggressive neuroendocrine malignancy, has limited treatment options beyond platinum-based chemotherapy, whereafter acquired resistance is rapid and common. By analyzing expression data from SCLC tumors, patient-derived models, and established cell lines, we show tha...

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Detalles Bibliográficos
Autores principales: Payapilly, Aishwarya, Guilbert, Ryan, Descamps, Tine, White, Gavin, Magee, Peter, Zhou, Cong, Kerr, Alastair, Simpson, Kathryn L., Blackhall, Fiona, Dive, Caroline, Malliri, Angeliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595642/
https://www.ncbi.nlm.nih.gov/pubmed/34758330
http://dx.doi.org/10.1016/j.celrep.2021.109979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595642/
https://www.ncbi.nlm.nih.gov/pubmed/34758330
http://dx.doi.org/10.1016/j.celrep.2021.109979

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