An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors

Micronuclei are a hallmark of cancer and several other human disorders. Recently, micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements that may drive tumor evolution and progression. Here, we show that Aurora B kinase mediates a surveillance mechanism that integr...

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Detalles Bibliográficos
Autores principales: Orr, Bernardo, De Sousa, Filipe, Gomes, Ana Margarida, Afonso, Olga, Ferreira, Luísa T., Figueiredo, Ana C., Maiato, Helder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595644/
https://www.ncbi.nlm.nih.gov/pubmed/34758324
http://dx.doi.org/10.1016/j.celrep.2021.109783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595644/
https://www.ncbi.nlm.nih.gov/pubmed/34758324
http://dx.doi.org/10.1016/j.celrep.2021.109783

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