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An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors
Micronuclei are a hallmark of cancer and several other human disorders. Recently, micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements that may drive tumor evolution and progression. Here, we show that Aurora B kinase mediates a surveillance mechanism that integr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595644/ https://www.ncbi.nlm.nih.gov/pubmed/34758324 http://dx.doi.org/10.1016/j.celrep.2021.109783 |