Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF(V600E)-Mutant Human Glioma

PURPOSE: Selective RAF-targeted therapy is effective in some patients with BRAF(V600E)-mutated glioma, though emergent and adaptive resistance occurs through ill-defined mechanisms. EXPERIMENTAL DESIGN: Paired pre-/post- RAF inhibitor (RAFi)-treated glioma samples (N = 15) were obtained and queried...

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Detalles Bibliográficos
Autores principales: Schreck, Karisa C., Morin, Andrew, Zhao, Guisheng, Allen, Amy N., Flannery, Patrick, Glantz, Michael, Green, Adam L., Jones, Chris, Jones, Kenneth L., Kilburn, Lindsay B., Nazemi, Kellie J., Samuel, David, Sanford, Bridget, Solomon, David A., Wang, Jiawan, Pratilas, Christine A., Nicolaides, Theodore, Mulcahy Levy, Jean M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595717/
https://www.ncbi.nlm.nih.gov/pubmed/34433654
http://dx.doi.org/10.1158/1078-0432.CCR-21-2660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595717/
https://www.ncbi.nlm.nih.gov/pubmed/34433654
http://dx.doi.org/10.1158/1078-0432.CCR-21-2660

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