Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens

Bacterial human pathogens secrete initially inactive nucleotidyl cyclases that become potent enzymes by binding to actin inside eukaryotic host cells. The underlying molecular mechanism of this activation is, however, unclear. Here, we report structures of ExoY from Pseudomonas aeruginosa and Vibrio...

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Detalles Bibliográficos
Autores principales: Belyy, Alexander, Merino, Felipe, Mechold, Undine, Raunser, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595890/
https://www.ncbi.nlm.nih.gov/pubmed/34785651
http://dx.doi.org/10.1038/s41467-021-26889-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595890/
https://www.ncbi.nlm.nih.gov/pubmed/34785651
http://dx.doi.org/10.1038/s41467-021-26889-2

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