Chimeric Flaviviral RNA−siRNA Molecules Resist Degradation by The Exoribonuclease Xrn1 and Trigger Gene Silencing in Mammalian Cells

RNA is an emerging platform for drug delivery, but the susceptibility of RNA to nuclease degradation remains a major barrier to its implementation in vivo. Here, we engineered flaviviral Xrn1‐resistant RNA (xrRNA) motifs to host small interfering RNA (siRNA) duplexes. The xrRNA‐siRNA molecules self‐...

Descripción completa

Detalles Bibliográficos
Autores principales: Harvey, Cressida, Klassa, Sven, Finol, Esteban, Hall, Jonathan, Hill, Alyssa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596575/
https://www.ncbi.nlm.nih.gov/pubmed/34431199
http://dx.doi.org/10.1002/cbic.202100434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596575/
https://www.ncbi.nlm.nih.gov/pubmed/34431199
http://dx.doi.org/10.1002/cbic.202100434

Ejemplares similares