Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase

With increasing temperature, nucleobases in DNA become increasingly damaged by hydrolysis of exocyclic amines. The most prominent damage includes the conversion of cytosine to uracil and adenine to hypoxanthine. These damages are mutagenic and put the integrity of the genome at risk if not repaired...

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Detalles Bibliográficos
Autores principales: Kropp, Heike M., Ludmann, Samra, Diederichs, Kay, Betz, Karin, Marx, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596578/
https://www.ncbi.nlm.nih.gov/pubmed/34486208
http://dx.doi.org/10.1002/cbic.202100306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596578/
https://www.ncbi.nlm.nih.gov/pubmed/34486208
http://dx.doi.org/10.1002/cbic.202100306

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