Pyrrole Hemithioindigo Antimitotics with Near‐Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single‐Cell Precision

We report the first cellular application of the emerging near‐quantitative photoswitch pyrrole hemithioindigo, by rationally designing photopharmaceutical PHTub inhibitors of the cytoskeletal protein tubulin. PHTubs allow simultaneous visible‐light imaging and photoswitching in live cells, deliverin...

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Detalles Bibliográficos
Autores principales: Sailer, Alexander, Meiring, Joyce C. M., Heise, Constanze, Pettersson, Linda N., Akhmanova, Anna, Thorn‐Seshold, Julia, Thorn‐Seshold, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596636/
https://www.ncbi.nlm.nih.gov/pubmed/34460143
http://dx.doi.org/10.1002/anie.202104794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596636/
https://www.ncbi.nlm.nih.gov/pubmed/34460143
http://dx.doi.org/10.1002/anie.202104794

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