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Pyrrole Hemithioindigo Antimitotics with Near‐Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single‐Cell Precision
We report the first cellular application of the emerging near‐quantitative photoswitch pyrrole hemithioindigo, by rationally designing photopharmaceutical PHTub inhibitors of the cytoskeletal protein tubulin. PHTubs allow simultaneous visible‐light imaging and photoswitching in live cells, deliverin...
Autores principales: | Sailer, Alexander, Meiring, Joyce C. M., Heise, Constanze, Pettersson, Linda N., Akhmanova, Anna, Thorn‐Seshold, Julia, Thorn‐Seshold, Oliver |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596636/ https://www.ncbi.nlm.nih.gov/pubmed/34460143 http://dx.doi.org/10.1002/anie.202104794 |
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