Biocatalytic Asymmetric Cyclopropanations via Enzyme‐Bound Iminium Ion Intermediates

Cyclopropane rings are an important structural motif frequently found in many natural products and pharmaceuticals. Commonly, biocatalytic methodologies for the asymmetric synthesis of cyclopropanes rely on repurposed or artificial heme enzymes. Here, we engineered an unusual cofactor‐independent cy...

Descripción completa

Detalles Bibliográficos
Autores principales: Kunzendorf, Andreas, Xu, Guangcai, Saifuddin, Mohammad, Saravanan, Thangavelu, Poelarends, Gerrit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596749/
https://www.ncbi.nlm.nih.gov/pubmed/34490955
http://dx.doi.org/10.1002/anie.202110719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596749/
https://www.ncbi.nlm.nih.gov/pubmed/34490955
http://dx.doi.org/10.1002/anie.202110719

Ejemplares similares