Sex‐specific alterations in NAD+ metabolism in 3xTg Alzheimer’s disease mouse brain assessed by quantitative targeted LC‐MS

Levels of nicotinamide adenine dinucleotide (NAD+) are known to decline with age and have been associated with impaired mitochondrial function leading to neurodegeneration, a key facet of Alzheimer's disease (AD). NAD+synthesis is sustained via tryptophan‐kynurenine (Trp‐Kyn) pathway as de novo...

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Detalles Bibliográficos
Autores principales: van der Velpen, Vera, Rosenberg, Nadia, Maillard, Vanille, Teav, Tony, Chatton, Jean‐Yves, Gallart‐Ayala, Hector, Ivanisevic, Julijana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596789/
https://www.ncbi.nlm.nih.gov/pubmed/33829502
http://dx.doi.org/10.1111/jnc.15362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596789/
https://www.ncbi.nlm.nih.gov/pubmed/33829502
http://dx.doi.org/10.1111/jnc.15362

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