Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent

We describe maleic‐acid derivatives as robust cysteine‐selective reagents for protein labelling with comparable kinetics and superior stability relative to maleimides. Diamide and amido‐ester derivatives proved to be efficient protein‐labelling species with a common mechanism in which a spontaneous...

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Detalles Bibliográficos
Autores principales: Laserna, Victor, Abegg, Daniel, Afonso, Cláudia F., Martin, Esther M., Adibekian, Alexander, Ravn, Peter, Corzana, Francisco, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596790/
https://www.ncbi.nlm.nih.gov/pubmed/34472678
http://dx.doi.org/10.1002/anie.202108791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596790/
https://www.ncbi.nlm.nih.gov/pubmed/34472678
http://dx.doi.org/10.1002/anie.202108791

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